Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network

Gene expression variation between species is a major contributor to phenotypic diversity, yet the underlying flexibility of transcriptional regulatory networks remains largely unexplored. Transcription of the ribosomal regulon is a critical task for all cells; in S. cerevisiae the transcription factors Rap1, Fhl1, Ifh1, and Hmo1 form a multi-subunit complex that controls ribosomal gene expressi...

متن کامل

Evolutionary tinkering with transposable elements.

I t was almost 30 years ago when François Jacob declared that evolutionary innovation (the emergence of novel form and function over time) occurred primarily via a process of ‘‘tinkering’’ (1). By tinkering, Jacob essentially meant the creation of novelty through random combinations of preexisting forms. Two fundamental and countervailing notions are implicit in this view of evolution: optimali...

متن کامل

Evolutionary dynamics of prokaryotic transcriptional regulatory networks.

The structure of complex transcriptional regulatory networks has been studied extensively in certain model organisms. However, the evolutionary dynamics of these networks across organisms, which would reveal important principles of adaptive regulatory changes, are poorly understood. We use the known transcriptional regulatory network of Escherichia coli to analyse the conservation patterns of t...

متن کامل

Escherichia coli transcriptional regulatory network

Escherichia coli is the most well-know bacterial model about the function of its molecular components. In this review are presented several structural and functional aspects of their transcriptional regulatory network constituted by transcription factors and target genes. The network discussed here represent to 1531 genes and 3421 regulatory interactions. This network shows a power-law distribu...

متن کامل

Inference in a Gene Regulatory Network with Transcriptional Time Delay

Background: Ordinary differential equations (ODEs) are an important tool for describing the dynamics of biological systems. However, for ODE models to be useful, their parameters must first be calibrated. Parameter estimation, that is, finding parameter values given experimental data, is an inference problem that can be treated systematically through a Bayesian framework. A Markov chain Monte M...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: PLoS Biology

سال: 2010

ISSN: 1545-7885

DOI: 10.1371/journal.pbio.1000329